First ;God says sons of God and daughters of men. Not sons of God and daughters of God, or sons of men and daughters of men. God never says anything without a reason. The sons of God are NOT sons of men, but only sons of God.
Second, right after God tells about these sons of God having sex with the daughters of men, He says He is going to destroy all life on the earth.
6 When human beings began to increase in number on the earth and daughters were born to them, 2 the sons of God saw that the daughters of humans were beautiful, and they married any of them they chose. 3 Then the Lord said, “My Spirit will not contend with humans forever, for they are mortal; their days will be a hundred and twenty years.”
Men were not forbidden to marry women, but God told them to marry and have children. There had to be a terrible sin for God to destroy life on the earth. That sin was Satan deceived many of the fallen angels, who followed him ,to have sex with women. The fallen angels were unredeemable. Man can be redeemed for hating God because he does not know God. Man can come to know God and therefore come to love God and be redeemed. The fallen angles knew God and yet hated him. Nothing can be done to save them. They hate God even though they know Him.
The whole human race was close to being made unredeemable by mixing with fallen angels. Their offspring were part fallen angel, and so unredeemable. Satan was close to having victory by ruining the whole human race. God saved the human race by destroying those who were part human and part fallen angel. He also put the fallen angles who did this into chains - Jude 1:6 And the angels who did not keep their positions of authority but abandoned their proper dwelling—these he has kept in darkness, bound with everlasting chains for judgment on the great Day.
Genesis 6:9 KJV - These are the generations of Noah: Noah was a just man and perfect in his generations, and Noah walked with God. - Noah's clan was the only group on the earth that had not done this and so God saved them from the flood and started the human race again with Noah.
Men have mixed with very sinful women and God did not destroy life on earth because of their sin. But when fallen angels mixed with women and their offspring was not able to be redeemed, God had to destroy them to keep them from ruining the whole human race. If every human was part fallen angel there would be no woman for Him to be born of; and for Him to become a man to shed His blood to save us.
This is the same deception Satan will use before Jesus returns. Jesus said it will be as in the days of Noah. Satan will try to make the human race trans-human by deceiving men into changing their DNA into something not totally human. I see the Covid vaccine that changes our DNA as a possible first step to this.
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